12.Impaired Autophagy: When Cells Forget to Take Out the Trash

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Autophagy literally means “self-eating”—a natural process where cells clean out damaged parts, recycle useful materials, and maintain overall health. But with age, autophagy becomes impaired, leading to an accumulation of cellular “junk” that clogs up systems and speeds up aging.

Picture a city where garbage collectors go on permanent strike. Streets fill up with trash, disease spreads, and life becomes miserable. That’s what happens at a microscopic level without autophagy.

Fortunately, certain supplements can help stimulate autophagy, helping cells stay clean, efficient, and youthful.

Top Supplements for Enhancing Autophagy

SupplementFunction
SpermidineDirectly promotes autophagy and cellular rejuvenation.
BerberineMimics fasting by activating AMPK, promoting cellular cleanup.
ResveratrolBoosts autophagy via sirtuin activation.
CurcuminEncourages autophagy and reduces cellular waste buildup.
Green Tea Extract (EGCG)Activates autophagy pathways and fights oxidative stress.

Natural Ways to Boost Autophagy

  • Practice intermittent fasting—fasting periods naturally trigger autophagy.
  • Exercise regularly—physical activity boosts cellular cleaning mechanisms.
  • Eat a clean, low-sugar diet—sugar inhibits autophagy.
  • Prioritize quality sleep—deep sleep is when major cellular cleanup happens.

Keeping your body’s cleanup crew active is like hiring an elite housekeeping service for your cells—keeping everything sparkling clean and functioning at its peak.

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