Your body is constantly folding, unfolding, and refolding proteins. It’s like a never-ending game of origami at the cellular level. Proteostasis refers to the balance of protein creation, maintenance, and recycling. But as we age, this balance breaks down, leading to misfolded, damaged proteins that clog up cells—contributing to diseases like Alzheimer’s, Parkinson’s, and others.
Imagine your house if you never took out the trash. Eventually, you wouldn’t even be able to walk inside! That’s what happens to aging cells when proteostasis fails.
Luckily, supplements can enhance your body’s ability to manage and recycle proteins, promoting healthier aging.
Top Supplements for Proteostasis
| Supplement | Function |
| Berberine | Activates autophagy, the cell’s natural cleaning and recycling process. |
| Spermidine | Promotes autophagy, helping cells clear out damaged proteins. |
| Green Tea Extract (EGCG) | Supports proteasome function and helps prevent protein aggregation. |
| Curcumin | Helps manage inflammation and supports proper protein folding. |
| Heat Shock Protein Boosters (e.g., N-acetylcysteine, HSP70 Activators) | Promote the correct folding of new proteins and repair of damaged ones. |
Easy Ways to Boost Proteostasis Naturally
- Practice intermittent fasting—it triggers cellular cleaning (autophagy).
- Get regular exercise—especially strength training.
- Avoid chronic stress—it disrupts cellular homeostasis.
- Include a variety of plant foods—they provide nutrients that support protein maintenance.
Taking care of your cellular housecleaning means clearer thinking, better movement, and a stronger, younger body.
